Pharmacological Studies of Houttuyniae Herba : The Anti-inflammatory Effect of Quercitrin

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  • ジュウヤク(Houttuyniae Herba)の薬理学的研究 : クエルシトリンの抗炎症作用
  • ジュウヤク Houttuyniae Herba ノ ヤクリガクテキ ケンキュウ

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Anti-inflammatory activities of quercitrin (Qu) were studied using various experimental models in mice, rats and guinea pigs. Qu (50, 100 and 200 mg/kg, p.o.) inhibited the rat hind paw edema induced by various phlogistics (carrageenin, dextran, histamine, serotonin and bradykinin) in a dosedependent manner, and 200 mg/kg of this compound also inhibited the scald edema induced by hot water (54°C). Qu did not show any significant inhibition of the ultraviolet light-induced erythema in guinea-pigs and of the increase of vascular permeability induced by acetic acid in mice. Qu did not affect the granuloma formation in a cotton pellet and the development of adjuvant arthritis in rats. These results indicate that Qu might have an inhibitory effect on acute inflammation.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 113 (4), 327-333, 1993

    The Pharmaceutical Society of Japan

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