Studies on Reversing Effect of Multidrug Resistance by Dipyridamole. I. Modulation of Epirubicin-Induced Effects on Cell Proliferation and Cell Cycle by Dipyridamole
Bibliographic Information
- Other Title
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- ジピリダモールの多剤耐性克服作用に関する研究(第1報)ジピリダモールによるエピルビシンの細胞増殖, 細胞周期に対する作用の修飾
- ジピリダモール ノ タザイ タイセイ コクフク サヨウ ニカンスルケンキュウ
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Description
Dipyridamole, a nucleoside membrane transport inhibitor, enhanced the cytotoxicity of epirubicin for mouse leukemia P388 cells by a factor of 1.8-fold and that for 30-fold doxorubicin-resistant sublines of P388 cells (P388/DOX) by a factor of 6.5-fold. This interaction was shown to be truly synergistic by DNA histogram and median effect analysis. The dipyridamole enhancement of the cytotoxicity of epirubicin was a dose-dependent effect ; it was greatest when cells were exposed to dipyridamole before treatment with epirubicin. In cell cycle experiments, 1-5μM dipyridamole increased the accumulation of G2+M phase produced by the treatment with 0.5-1μM epirubicin. Dipyridamole, however, did not appear to alter the patterns of DNA histogram in sensitive cells. These results suggest that the increase of the accumulation of G2+M phase in resistant cells is an important factor for the interaction between epirubicin and dipyridamole.
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 116 (3), 217-227, 1996
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001206154877952
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- NII Article ID
- 110003661126
- 130007277964
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 3938433
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed