Induction of Biological Activities by Chemically Modified Subfragments from Human Serum IgG and Their Application to Development of Medicine

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  • ヒト血清IgGの化学修飾による新規活性の誘導と医薬品開発への応用
  • ヒト ケッセイ IgG ノ カガク シュウショク ニヨル シンキ カッセイ ノ

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Description

Immunoglobulin G (IgG) is an important protein in humoral immunity. After IgG binds to the specific foreign antigen, IgG-antigen complexes are eliminated either by making it easier for a phagocytic cell to ingest them or by activating a complement system. We found that the carboxyamidemethylated subfragments obtained from human serum IgG by reduction and alkylation of its interchain disulfide bonds, have anti-ulcerogenic, anti-inflammatory and antiallergic activities, while no activity was recognized in the original IgG. On the other hand, some saturated and unsaturated fatty acids generally existing in microorganisms were found to have anti-inflammatory and anti-ulcerogenic activities. As the application of these researches, we synthesized hybrid compounds from sulfur-containing amines and fatty acids to make a lead compound for developing a new medicine. In this review, the experimental process will be discussed.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 116 (5), 374-387, 1996

    The Pharmaceutical Society of Japan

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