書誌事項
- タイトル別名
-
- Nutritional and Biochemical Studies on Vitamin D and Its Active Derivatives
- ビタミン D オヨビ ソノ カッセイ ユウドウタイ オ チュウシン ト シタ
この論文をさがす
抄録
We have performed nutritional and biochemical studies on vitamin D and its active derivatives and the following results are obtained. 1. Since recent studies have revealed that dietary supplement of vitamin D (D2 and D3) and calcium is effective for preventing osteoporosis, a simplified routine method for determination of vitamin D in foods is established and applied to the assay on the contents of vitamin D in various kinds of Japanese foods. 2. A simplified routine method for simultaneous determination of vitamin D and its metabolites in the plasma and milk is established and applied to nutritional and clinical studies. 3. Physiological activities of two kinds of novel vitamin D3 derivatives, 22-oxa-1α, 25-dihydroxyvitamin D3 (22-oxa-1, 25 (OH)2D3, OCT) and 2β-(3-hydroxypropoxy)-1, 25 (OH)2D3 (ED-71) have been studied. OCT, which has less calcemic and stronger cell differentiationon activities than 1, 25 (OH)2D3, is a candidate for curing leukemia and other cancers without hypercalcemia. We have clarified that the property is due to its weak binding affinity for vitamin D binding protein and rapid turn-over in the body and rapid excretion into bile. On the other hand, ED-71, which has stronger effects on intestinal calcium absorption and longer bone turn-over than 1, 25 (OH)2D3, is a candidate for curing osteoporosis. We have clarified that the properties are due to stronger binding affinity for DBP and longer half-life than 1, 25 (OH)2D3.
収録刊行物
-
- 薬学雑誌
-
薬学雑誌 116 (6), 457-472, 1996
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001206154966528
-
- NII論文ID
- 110003649037
-
- NII書誌ID
- AN00284903
-
- ISSN
- 13475231
- 00316903
-
- NDL書誌ID
- 3987749
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可