書誌事項
- タイトル別名
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- Studies on the Synthesis of Cholecystokinin A Receptor Antagonists. I. Synthesis and Cholecystokinin A Receptor Inhibitory Activities of Malonamide Derivatives
- コレシストキニン A ジュヨウタイ キッコウザイ ノ ゴウセイ ケンキュウ ダ
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抄録
2-Substituted malonamide derivatives were synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity. Significant CCK-A receptor inhibitory activities were found in only three compounds (4g-i) which have carboxyl group. In order to study structure-activity relationships, carboxyethyl group was selected for 2-substituent and a number of N-substituted malonamides were prepared. After these compounds were tested for CCK-A receptor inhibitory activity, 4-(3, 4-dichlorophenylcarbamoyl)-N, N-dipentylglutaramic acid (4h) was selected as the most preferred compound.
収録刊行物
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- 薬学雑誌
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薬学雑誌 116 (1), 50-58, 1996
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206155071488
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- NII論文ID
- 110003648994
- 130007278344
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 3919647
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- データソース種別
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- JaLC
- NDL
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