Synthesis of <i>p</i>-Aminohippuric Acid

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Other Title
  • パラアミノ馬尿酸の合成について
  • パラアミノ バニョウサン ノ ゴウセイ ニ ツイテ

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Description

Treatment of aminoacetonitrile with sodium hydroxide yielded a sodium solution of glycocoll to which p-nitrobenzoyl chloride was reacted to obtain p-nitrohippuric acid. In this instance a monohydrate of pale yellow prisms, m.p. 130-132°, is obtained at pH 1.0-1.5 and that of white needles, m.p. 190-192°, at pH 4.0-4.5. These two transit to each other by the correction of pH. Catalytic reduction of p-nitrohippuric acid yielded p-aminohippuric acid.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 71 (12), 1494-1496, 1951

    The Pharmaceutical Society of Japan

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