書誌事項
- タイトル別名
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- Antiviral Compounds. XVI. Antiviral Activity of 1, 2, 4-Triazines
- 抗ウィルス化合物-16-1,2,4-Triazine類の抗ウィルス活性
- コウ ウィルス カゴウブツ 16 1 2 4-Triazineルイ ノ コウ
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抄録
3-Alkylthio- and 3-hydrazino-1, 2, 4-triazines were synthesized and examined for their antiviral activities against influenza virus A2/Adachi strain in the chorio-allantoic membrane culture. 3-Alkylthio-1, 2, 4-triazines exhibited weak inhibitory and relatively strong virucidal activities. The most active 3-hexylthio- and 3-octylthio-6-methyl-5-phenyl-1, 2, 4-triazines showed the virucidal activity at a concentration of 0.32 μg/ml. Similarly to 3-alkylthio derivatives, 3-(substituted benzylidenehydrazino)-6-(4-chlorophenyl)-1, 2, 4-triazines exhibited weak inhibitory and relatively strong virucidal activities. The most active compounds were 3-(4-acetaminobenzylidenehydrazino)- and 3-(9-chloro-10-anthridenehydrazino)-6-(4-chlorophenyl)-1, 2, 4-triazines, and they showed a 50% virucidal concentration of 0.51 μg/ml. 3-Hydrazino-1, 2, 4-triazines exhibited weak inhibitory and virucidal activities. 3-Isopropylidenehydrazino-1, 2, 4-triazines exhibited relatively strong inhibitory and virucidal activities. 5-Methyl-6-phenyl derivative showed a 50% inhibitory concentration of 6.25 μg/ml and 6-methyl-5-phenyl derivative exhibited a 50% virucidal concentration of 0.1 μg/ml.
収録刊行物
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- 薬学雑誌
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薬学雑誌 107 (4), 301-307, 1987
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206155260032
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- NII論文ID
- 110003649767
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 3137320
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- データソース種別
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- JaLC
- NDL
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