The Behavior of 1, 4-Benzodiazepine Drugs in Acidic Media. IX. Effect of Hydrolyzate of flutazolam on the Central Nervous System

DOI Web Site Web Site

Bibliographic Information

Other Title
  • 1,4-Benzodiazepine系医薬品の酸性水溶液中における挙動(第9報)Flutazolamの加水分解生成物の中枢作用
  • 1,4-Benzodiazepine系医薬品の酸性水溶液中における挙動-9-Flutazolamの加水分解生成物の中枢作用
  • 1 4 Benzodiazepineケイ イヤクヒン ノ サンセイ スイヨウエ

Search this article

Abstract

Effects of hydrolizate (III·HCl) of Flutazolam (I) on the antianxiety, the anticonvulsion, the prolongation of the sleep, the muscle relaxation and the antihypoxia were compared with I in mice by the established methods. It was demonstrated that III·HCl inhibited the anxiety and pentetrazol-induced convulsion, prolonged the thiopental-induced sleep, and produced the skeletal muscle relaxation and the protection against hypobaric-hypoxia. These potencies of III·HCl were equipotent to I. These results suggested that III·HCl might be able to be delivered in an injection form.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 107 (10), 830-834, 1987

    The Pharmaceutical Society of Japan

Keywords

Details 詳細情報について

Report a problem

Back to top