Pharmacological Study on Aconiti Tuber. I. Effect of Water Extract from Aconiti Tuber on Adjuvant-Induced Arthritis
Bibliographic Information
- Other Title
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- 漢薬・炮附子の薬理活性研究(第1報)アジュバント関節炎に及ぼす炮附子水抽出エキスの影響
- 漢薬・炮附子の薬理活性研究-1-アジュバント関節炎に及ぼす炮附子抽出エキスの影響
- カンヤク ホウブシ ノ ヤクリ カッセイ ケンキュウ 1 アジュバント カンセ
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Description
Anti-inflammatory activity of a hot water extract (A-ext) of Aconiti Tuber (Aconitum calmicaeli DEBX.) has been studied by using various experimental models. The succesive administration of A-ext from the day of injection of adjuvant agent or 5 d after the injection it significantly inhibited the adjuvant-induced arthritis developed in the primary and secondary lesions in rats. However, when A-ext was administered from 11 d after the injection of adjuvant, the arthritic paw edema was not reduced. A-ext did not inhibit an acetic acid-induced increase in vascular permeability in mice and carrageenin-induced paw edema in rats. A-ext inhibited cotton pellet-induced granuloma in rats, but did not suppress the weight of thymus and adrenal gland. In vitro experiment, A-ext contracted the isolated ileum of guinea pig, but the contractive activity was reduced by pretreatment of anti-histamine agent, diphenhydramine, but not by pretreatment of papaverine or atropine. A-ext did not release histamine from peritoneal mast cell. These results suggest that A-ext prevents the adjuvant-induced arthritis and bas a histamine-like effect.
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 110 (1), 16-26, 1990
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001206155689984
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- NII Article ID
- 130007279579
- 110003649939
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 3659444
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed