Isosorbide Dinitrateに関する研究(第2報)Isosorbide 5-Mononitrateの血中濃度測定法と体内動態

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タイトル別名
  • Studies on Isosorbide Dinitrate. II. Determination of Isosorbide 5-Mononitrate in Human Plasma and Pharmacokinetics
  • Isosorbide Dinitrateに関する研究-2-Isosorbide 5-Mononitrateの血中濃度測定法と体内動態
  • Isosorbide Dinitrate ニ カンスル ケンキュウ 2 Iso

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In connection with our studies on the determination of isosorbide dinitrate (ISDN), a high sensitive determination of isosorbide 5-mononitrate (5-ISMN) in the human plasma was developed by using electron capture detector gas chromatography on a silicone OV-101 fused silica capillary column. 5-ISMN was extracted with ether from the plasma and reacted with acetyl chloride. This method provided linear calibration curve ranging 1 to 50ng/ml and the limit of detection was 1ng/ml in the human plasma. The measurement of plasma concentration of ISDN and 5-ISMN after a single oral administration of ISDN tablet and a single application of sustained-release ISDN tape by our method were satisfactory. Thus, this method was applicable to pharmacokinetic studies of ISDN preparations.

収録刊行物

  • 薬学雑誌

    薬学雑誌 107 (1), 65-69, 1987

    公益社団法人 日本薬学会

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