The Effect of Combined Use of Aminopyrine and Barbital on the Blood Concentration, and the Action of Drugs. II

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  • Ohata Katsuya
    Department of Pharmacology, Medical Faculty, University of Kyoto

Bibliographic Information

Other Title
  • アミノピリン及びバルビタール併用下に於ける各薬物の血中濃度と作用について (第2報)

Description

A mixture of aminopyrine and barbital, in a molar ratio of 1:1, and their molecular compound were administered to rabbits and blood level and action of both components were comparatively examined. It was thereby found that the administration of the mixture and molecular compound effected lowering of initial blood level and decrease of toxicity in aminopyrine, and lowering of initial blood level, rise of final blood level, and prolongation of anesthetic action in barbital, as compared to the administration of each drug alone. No significant difference was observed in the blood level and physiological action between the said mixture and molecular compound.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 78 (3), 312-314, 1958

    The Pharmaceutical Society of Japan

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