Mass Spectrometryによる製剤分析(第7報) : 解熱鎮痛剤の分析その3 : フェナセチン, ピリナジン, パスの高分解能質量スペクトル

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タイトル別名
  • Analysis of Mixed Drugs by Mass Spectrometry.VII. : Analysis of Antifebrile.(3). : High-Resolution Mass Spectra of Phenacetin, Pyrinazine and 4-Aminosalicylic Acid
  • Spectrometryによる製剤分析-7-解熱鎮痛剤の分析-3-フェナセチン,ピリナジン,パスの高分解能質量スペクトル
  • Spectrometry ニ ヨル セイザイ ブンセキ 7 ゲネツ チンツウザイ ノ ブンセキ 3 フェナセチン , ピリナジン , パス ノ コウ ブンカイノウ シツリョウ スペクトル

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There are numerous organic compounds which possess both hydroxyl and amino groups in their molecule. Since O and NH2 both have a mass number of 16, it becomes a problem which had been eliminated in fragmentation. The analysis of their fragmentation is often carried out by their labeling with 2H, 18O or 15N but labeling with isotopes is rather limited and the procedure is often difficult. Following previous reports on the mass spectrometry of aromatic compounds having both hydroxyl and amino groups in their molecule, particularly in those of antipyretics such as acetophenetidine (4-ethoxyacetanilide), pyrinazine (4-hydroxyacetanilide), and 4-aminosalicylic acid, their spectra were measured with a doublefocusing high-resolution mass spectrometer and their fragmentation was examined.

収録刊行物

  • 薬学雑誌

    薬学雑誌 87 (4), 329-337, 1967

    公益社団法人 日本薬学会

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