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- 上野 高正
- 財団法人結核予防会結核研究所
書誌事項
- タイトル別名
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- Influence of Metal Ions on the <i>in vitro</i> Activity of Antituberculosis Agents and its Relation to Metal Complex Formation. I
- 抗結核剤に対する金属イオンの影響
- The Influence of Metal Ions on the Activity of Antituberculosis Agents
抄録
The growth inhibiting concentration of p-aminosalicylic acid (PAS), isonicotinic acid hydrazide (INAH), thioacetazone (TB-1), streptomycin (SM), and dihydrostreptomycin (DHSM) in a Kirchner medium containing 10% horse serum against human-type tubercle bacilli H37Rv strain and its resistant strains to INAH, TB-1, SM, and DHSM, and PAS, is sometimes affected by the addition of excess of Ca, Cu, Ni, Fe (III), Al, Hg, Mg, Zn, Mn, Cd, and Co (II). The effect is either synergism or antagonism. The difference between synergism, antagonism, and no-effect occurs by the difference in the combination of antitubercular agents, the kind of metal used, and sensitivity or resistance of the bacillus used. The combination effective to sensitive strains may not affect resistant strains or simply remain effective. Sometimes, the combination may affect only the resistant strains. Detailed examination of the synergism-antagonism caused by different concentrations of the metal indicated that higher the concentration of the metal, the stronger was synergism while antagonism was found within a narrow concentration range of a combination of SM or DHSM and aluminum. The molar ratio of the antitubercular agent and metal combination which showed synergism was 5-0.005:1 in sensitive strains and 518-5:1 in resistant strains. In a combination of SM and mercury, this ratio was 0.5-0.15:1 in sensitive strains and 518-168:1 in resistant strains. The minimum effective concentration of mercury in such cases was 3.4×10-6 M and 1.1×10-6 M. The present experimental results would not support the hypothesis that the direct action of a metal on bacillus or a metal complex salt is effective.
収録刊行物
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- 薬学雑誌
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薬学雑誌 76 (7), 825-830, 1956
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206187488384
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- NII論文ID
- 130007284982
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- ISSN
- 13475231
- 00316903
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可