Influence of Metal Ions on the <i>in vitro</i> Activity of Antituberculosis Agents and its Relation to Metal Complex Formation. II

DOI Web Site
  • Ueno Takamasa
    Research Institute for Tuberculosis, Japan Antituberculosis Association

Bibliographic Information

Other Title
  • 抗結核剤の試験管内作用に対する金属イオンの影響と錯塩形成との関連 (第2報)
  • 抗結核剤の金属錯塩形成に関する検討
  • Investigation on the Metal Complex Formation of Antituberculosis Agents

Abstract

Formation of a complex salt was examined in 55 combinations of antitubercular agents, PAS, INAH, TB-1, SM, and DHSM with Ca, Co, Ni, Fe (III), Al, Hg, Mg, Zn, Cd, and Co (II). In order to find out the state in lower concentrations, effect of metal addition on the ultraviolet absorption curve of aqueous solutions of PAS, INAH, and TB-1 and that of addition of SM or DHSM on the ultraviolet absorption curve of aqueous solution of metals were observed. The breaking point in the high frequency titration curves obtained by the dropwise addition of an aqueous solution of antitubercular agent into metal solution was also examined. As for changes in the ultraviolet absorption curves, a shift of the maximum absorption was observed in a combination of PAS with Al or Hg, INAH and Hg, TB-1 with Cu and Hg, SM and Cu, and DHSM and Cu, a change in wave form in that of PAS and Fe (III), and a change in absorbancy at the maximum absorption in combinations of PAS with Cu, Al, and Hg, INAH with Cu, Ni, Hg, and Mn, TB-1 with Cu, Fe (III), Al, and Hg, SM with Co, Fe (III), Hg, Zn, and Mn, and DHSM with Ca and Cu. Appearance of a breaking point in high frequency titration curve was observed in combination of PAS with Co, Ni, Fe (III), Al, Hg, Mg, and Mn, INAH with Ca, Co, Ni, Fe (III), Hg, Zn, and Co (II), TB-1 with Ca, Co, Ni, Fe (III), Al, Hg, and Mn, SM with Al, Hg, and Mg, and DHSM with Al and Hg. The result from the second method agreed by 63.6%, complex formation was observed in eight combinations by the ultraviolet absorption and in 12 combinations by the high frequency titration alone.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 76 (7), 831-838, 1956

    The Pharmaceutical Society of Japan

Keywords

Details 詳細情報について

Report a problem

Back to top