Physico-Chemical Studies of the Mixed Membrane composed of Gelatin and Chondroitin Sulfate. I. pH Dependence and Anisotropy of the Swelling

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Other Title
  • ゼラチン, コンドロイチン硫酸混合膜の物理化学的研究(第1報)膨潤のpH変化および異方性について
  • ゼラチン,コンドロイチン硫酸混合膜の物理化学的研究-1-膨潤のpH変化および異方性について
  • ゼラチン コンドロイチン リュウサン コンゴウ マク ノ ブツリ カガクテキ

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Abstract

The membranes used were the gelatin membrane and the mixed membrane composed of gelatin and chondroitin sulfate-C (chs), and these were cross-linked by formaldehyde in order to make them insoluble. The weight ratio of chs to gelatin in the mixed membrane was 0.342. pH dependence of the swelling was measured in the range of pH 2.8-8.1 using McIlvaine buffer solution. The result obtained from the gelatin membrane was different from that of the mixed membrane. In the former, the degree of swelling increased with decreasing pH, while in the latter, it became maximum at the vicinity of pH 4.9 which is the isoionic point pH of gelatin. These results satisfied the following equation of the swelling rate, e.g., d(WW/WM)/dt=k(WW/WM), where (WW/WM) is the weight of water per gram of membrane constituent, and k is the constant of the swelling rate. The value of k, in various pH solutions was thus obtained. The swelling of these membranes was anisotropic, e.g., the thickness increased but the radius hardly increased. In the case of the mixed membrane, the anisotropy of swelling was so pronounced that the radius decreased in the acidic region. From these results, orientation of the molecules in the membrane was discussed.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 95 (1), 75-81, 1975

    The Pharmaceutical Society of Japan

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