書誌事項
- タイトル別名
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- Synthesis of N-(2-Piperazinoethyl) propionanilides
- N 2 Piperazinoethyl propionanilideルイ ノ
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抄録
N-(2-Piperazinoethyl) propionanilides were synthesized by the reduction of piperazino-acetanilide or the condensation of N-(β-bromoethyl) aniline hydrobromide and piperazines. Comparing the two methods, the condensation method is superior from the point of yield and easiness. The analgesic activity test showed that (A) N-[1-methyl-2-(4-methylpiperazino) ethyl] propionanilide (7a) possessed ca. 1/9 of the analgesic effect of morphine, and N-[2-(4-phenethylpiperazino) ethyl] propionanilide (7e) and N-[2-(3-methyl-4-phenethylpiperazino) ethyl] propionanilide (7i) possessed ca. 1/2 of the analgesic effect of pentazocine ; (B) the compound (7a), (7e), (7i) showed strong acute toxicities ; (C) methyl group at the 3-position of piperazine ring decreased analgesic activity ; (D) phenyl group at the 3-position of piperazine ring deactivated the analgesics.
収録刊行物
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- 薬学雑誌
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薬学雑誌 98 (12), 1619-1628, 1978
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206215156480
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- NII論文ID
- 130007285599
- 110003652709
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 2077193
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- データソース種別
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- JaLC
- NDL
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- 使用不可