Indolizine誘導体の合成とその反応(第2報)

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書誌事項

タイトル別名
  • Synthesis of Indolizine Derivatives and Their Reactions. II
  • Indolizine導体の合成とその反応-2-
  • Indolizine ドウタイ ノ ゴウセイ ト ソノ ハンノウ 2

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説明

1-Azaindolizine derivatives (Va, b, c) were easily obtained by the reaction of dimethyl N-(2-methylpyridin-5-yl) dithiocarbimidate (III) and α-halogenocarbonyl derivatives (ethyl bromoacetate, ω-bromoacetophenone, and ethyl bromocrotonate). 1-Azaindolizine derivatives (II, Va) were oxidized with perphthalic acid to afford 2-methylsulfonylimidazo-[1, 2-a] pyridine derivatives (VIa, b). Va was brominated with N-bromosuccinimide to ethyl 5-bromomethyl-2-methylthioimidazo [1, 2-a] pyridine-3-carboxylate (XII), which reacted with ammonia and methylamine to afford dihydrodiazacycl [3.2.3] azine derivatives (XIII, XIV).

収録刊行物

  • 薬学雑誌

    薬学雑誌 98 (5), 631-635, 1978

    公益社団法人 日本薬学会

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