Inhibitory Effect of Gliclazide on Platelet Adhesiveness and Aggregation in Alloxan Diabetic Rabbits
Bibliographic Information
- Other Title
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- アロキサン糖尿ウサギの血小板粘着能および凝集能に対するGliclazideの抑制効果
- アロキサン トウニョウ ウサギ ノ ケッショウバン ネンチャクノウ オヨビ ギ
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Abstract
The inhibitory effect of gliclazide, a new sulfonylurea, on platelet function was examined in alloxan diabetic rabbits. The blood glucose level in diabetic rabbits was about 3 times higher than in normal rabbits, and the plasma insulin level was below 50% of that of normal rabbits. Platelet adhesiveness to glass beads and platelet aggregation by collagen were markedly enhanced in the diabetic rabbits. 2-4 week daily administration of gliclazide (100 mg/kg, p.o.) to diabetic rabbits effected the reduction of enhanced platelet adhesiveness, and platelet aggregation was also lowered to that of normal rabbits after 4 weeks. Blood glucose and plasma insulin levels, however, were not changed by the treatment. These results suggest that gliclazide exerts an inhibitory action on platelet function via mechanism (s) other than insulin secretion and glucose metabolism.
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 99 (1), 59-64, 1979
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001206215878400
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- NII Article ID
- 110003652900
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 2079399
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed