第3級アミンオキシドに関する研究(第63報)1-Cyanoisoquinoline 2-OxideおよびIsoquinoline 2-Oxideのニトロ化について
書誌事項
- タイトル別名
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- Studies on Tertiary Amine Oxides. LXIII. Nitration of 1-Cyanoisoquinoline 2-Oxide and Isoquinoline 2-Oxide
- 第3級アミンオキシドに関する研究-63-1-Cyanoisoquinoline 2-OxideおよびIsoquinoline 2-Oxideのニトロ化について
- ダイ 3キュウ アミンオキシド ニカンスルケンキュウ 63 1 Cyanois
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Nitration of 1-cyanoisoquinoline 2-oxide (1) with potassium nitrate and sulfuric acid gave 5-and 6-nitro derivatives (2 and 3). The reaction was affected by the concentration of sulfuric acid, and 3 was obtained in small yields as the sole product from the reactions in the 85% acid at 70°. Nitration with fuming nitric acid (d=1.50) led to the formation of 3 in fairly good yields together with small amounts of 8-nitro derivative (7). Further, nitration of isoquinoline 2-oxide (9) with fuming nitric acid was found to give 5-, 6- and 8-nitro derivatives (10, 11 and 12). The orienting effect of the N-oxide function is apparently operative in the formation of 11 and 12.
収録刊行物
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- 薬学雑誌
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薬学雑誌 99 (1), 23-29, 1979
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206215888896
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- NII論文ID
- 110003652895
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 2079406
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- データソース種別
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- JaLC
- NDL
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