ホルムアルデヒド及びアセトアルデヒドの定量分析におけるqNMRを用いたトレーサビリティの確保

DOI Web Site Web Site PubMed 参考文献5件

書誌事項

タイトル別名
  • Ensuring Traceability Using qNMR in the Quantitative Analysis of Formaldehyde and Acetaldehyde
  • ホルムアルデヒド オヨビ アセトアルデヒド ノ テイリョウ ブンセキ ニ オケル qNMR オ モチイタ トレーサビリティ ノ カクホ

この論文をさがす

抄録

　Currently, indoor air quality guidelines for formaldehyde and acetaldehyde are set by the Ministry of Health, Labour and Welfare of Japan. Aldehydes are widely used in adhesives and preservatives, and exposure to these compounds via indoor air is a matter of concern. Considering that contact with indoor air is part of daily life, evaluation of indoor air quality is extremely important. 2,4-Dinitrophenylhydrazine (DNPH) derivatization is widely used for quantitative analysis of aldehydes. A certified reference material with traceability to the International System of Units (SI) is required for this method. However, currently, there are no certified reference materials available for aldehyde-DNPH derivatives, which means that the quantified values obtained by this method are not sufficiently reliable. In this study, we determined the actual content and purity of commercially available aldehyde-DNPH derivatives using 1H-quantitative NMR (qNMR), which can be measured with SI-traceability. Although the commercial DNPH derivatives of formaldehyde and acetaldehyde were low concentration solutions, we were able to determine their purities using 1H-qNMR. Furthermore, we were able to separate and quantify the acetaldehyde isomers generated by the derivatization reaction. In conclusion, it is possible to obtain highly accurate results using 1H-qNMR with commercially available reagents that are not certified metrologically.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 138 (4), 551-557, 2018-04-01

    公益社団法人 日本薬学会

参考文献 (5)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ