Visco-plastic Behavior of Powder in the Process of Dynamic Compression

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  • 打錠工程における薬剤の粘塑性挙動
  • ダジョウ コウテイ ニ オケル ヤクザイ ノ ネンソセイ キョドウ

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Abstract

We established a new method to quantitatively evaluate two types of consumed energies resulting from plastic deformation (Ep) and viscosity (Ev) of sample. To evaluate a new parameter (ΔE/ΔV), the tabletting velocity (V) dependence of Ev, was determined. We found that the total consumed energy (Et) consists of Ep and Ev, and the tabletting velocity dependence of Et is expressed as a simple first order equation, Et=a·V+b, where a and b mean ΔE/ΔV and Et, respectively. The parameter ΔE/ΔV is considered to express the grade of negative contribution of sample viscosity to the tabletting process.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 99 (4), 325-328, 1979

    The Pharmaceutical Society of Japan

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