複合体医薬品の性状に関する研究(第1報)アミノフィリンの示差熱天秤分析

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タイトル別名
  • Studies on the Properties of the Complex-Medicines. I. Differential Thermogravimetric Analysis of Aminophylline
  • 複合体医薬品の性状に関する研究-1-アミノフィリンの示差熱天秤分析
  • フクゴウタイ イヤクヒン ノ セイジョウ ニカンスルケンキュウ 1 アミノフィ

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説明

Liberation of ethylenediamine and crystal water from aminophylline JP was examined by differential thermal balance and X-ray diffraction methods. Differential thermal balance analysis of aminophylline, carried out in air, at the temperature elevation rate of 2.5°/min, showed that loss in weight started at around 67°, accompanied with endothermic peak which transited to a small endothermic peak, and the thermal change ended at around 130°when weight loss was completed. The thermal balance curve also showed changes corresponding to the two endothermic peaks. Samples were collected at various decomposition rates for analysis and it was found that there may be two routes of decomposition ; one in which aminophylline would lose ethylenediamine and crystal water and convert directly into anhydrous theophylline, and the other in which it loses a part of crystal water to change into aminophylline with about one-half molecule of crystal water (tentatively termed α-aminophylline) and then change into anhydrous theophylline. It was considered that the first endothermic peak corresponds to the overlapping of the process of conversion of aminophylline directly into anhydrous theophylline and the process of aminophylline changing into α-aminophylline, and the second endothermic peak corresponds to the process of liberation of ethylenediamine and crystal water from α-aminophylline.

収録刊行物

  • 薬学雑誌

    薬学雑誌 99 (8), 824-829, 1979

    公益社団法人 日本薬学会

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