Effects of Various Fatty Acids on Stabilization of Rat Erythrocyte and Carrageenin-induced Edema

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  • ラット赤血球膜安定化およびカラゲニン浮腫に対する脂肪酸類の影響
  • ラット セッケッキュウ マク アンテイカ オヨビ カラゲニン フシュ ニ タイ

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Abstract

Anti-inflammatory effect of C10-C20 saturated fatty acids was examined by using heat-induced hemolysis, hypotonic hemolysis, heat-induced denaturation of bovine serum albumin (BSA), and carrageenin-induced paw edema as the experimental systems. 1) Several fatty acids, including C13 : 0 to C17 : 0, were found to protect erythrocytes from heat-induced hemolysis, and C12 : 0 to C16 : 0 significantly inhibited hypotonic hemolysis in vitro. 2) All fatty acids tested showed a significant effect on heat-induced denaturation of BSA at a concentration of 5.0 μg/ml in vitro, but C16 : 0 methyl ester did not show any inhibitory effect at the same concentration. 3) Palmitic acid, its methyl ester, and oleic acid suppressed carrageenin-induced paw edema in rats by oral administration at the dosage of 200 mg/kg, but C16 : 0 methyl ester did not suppress it by intraperitoneal injection. 4) In adrenalectomized rats, palmitic acid also suppressed carrageenin-induced paw edema. 5) Palmitic acid inhibited the granuloma formation caused by felt-pellet at the dose of 100 mg/kg/day (oral) for 5 days, but did not show a significant effect on either exudation into the granuloma pouch or on formation of pouch wall.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 97 (11), 1246-1252, 1977

    The Pharmaceutical Society of Japan

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