書誌事項
- タイトル別名
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- Influence of the Enterohepatic Circulation on the Metabolism of Chlorphenesin Carbamate (CPC). I. Comparison between Guinea Pigs and Bile Duct-Ligated Rats
- Chlorphenesin Carbamate(CPC)の代謝におよぼす腸肝循環の影響-1-モルモットと胆管結紮ラットについて
- Chlorphenesin Carbamate CPC ノ タイシャ ニ オヨ
- Influence of the enterohepatic circulation on the metabolism of chlorphenesin carbamate (CPC). I. Comparison between guinea pig and bile duct-ligated rats
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In guinea pigs, chlorphenesin carbamate (CPC), a centrally acting skeletal muscle relaxant, was excreted rapidly in urine after oral administration of the 14C-labeled compound. During 5 days, about 93% of the dose administered was recovered from urine and only 2% appeared in feces. The glucuronide of CPC was the major metabolite which accounted for about 87% of the total radioactivity excreted in 48 hr urine and only 2.5% of the urinary radioactivity was excreted as the acidic metabolites including p-chlorophenoxylactic acid, p-chlorophenoxyacetic acid and p-chlorophenol. The biliary excretion of CPC after intravenous administration was less than 10% of the dose administered in guinea pigs, while it was about 42% in rats. The major metabolite found in the bile was the glucuronide in both species. In common bile duct-ligated rats, CPC markedly inhibited the spinal reflex but duration of the action was shorter than that in intact rats. A temporary rise of radioactivity, followed by rapid fall in blood and rapid excretion in urine were observed by the ligation of common bile duct after administration of 14C-CPC, as compared to those in intact rats. CPC was excreted mostly as its glucuronide and the excretion of acidic metabolites decreased markedly in these bile duct-ligated rats. Urinary acidic metabolites increased to a greater extent after oral administration than by a subcutaneous route.
収録刊行物
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- 薬学雑誌
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薬学雑誌 97 (11), 1189-1194, 1977
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206216810240
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- NII論文ID
- 130007287469
- 110003652464
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 1916527
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- データソース種別
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- JaLC
- NDL
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