Synthesis and Biological Activity of Sulfur Containing Derivatives of Chalcone I. : Synthesis and Antibacterial Action of Alkylthiochalcones

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  • 含硫カルコン誘導体の合成ならびにその生物活性について(第1報) : Alkylthiochalcone類の合成ならびに抗菌作用
  • 含硫カルコン誘導体の合成ならびにその生物活性について-1-Alkylthiochalcone類の合成ならびに抗菌作用
  • ガンリュウカルコン ユウドウタイ ノ ゴウセイ ナラビニ ソノ セイブツ カッセイ ニ ツイテ 1 Alkylthiochalconeルイ ノ ゴウセイ ナラビニ コウキン サヨウ

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Abstract

Alkylthiochalcones (IV-LIV) were synthesized by the condensation of alkylthioacetophenones (I-III) with aromatic aldehydes for the purpose of screening their antibacterial activity in vitro. Of these chalcone derivatives tested, 18 compounds (IV, VI, XII, XIII, XVI, XIX, XX, XXII, XXIII, XXVIII, XXX, XXXI, XXXII, XXXVI, XXXVII, XXXIX, IL, and LIII) showed a relatively intense antibacterial activity against Bacills subtilis NRRL, and VI was also effective against Escherichia coli O-55. XXXVIII revealed antibacterial action only against Staphylococcus aureus 209 P.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 91 (8), 804-810, 1971

    The Pharmaceutical Society of Japan

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