COMPARATIVE STUDIES ON EFFECTS OF INCOMPLETE OIL ADJUVANTS WITH DIFFERENT PHYSICAL PROPERTIES
-
- 後藤 紀久
- 国立予防衛生研究所一般検定部
書誌事項
- タイトル別名
-
- Comparative studies on effects of incom
この論文をさがす
説明
The author investigated the effects of Freund's incomplete adjuvant (FIA) with different physical properties on precipitin formation and skin hyperreactivity in rabbits and mice following intramuscular injection of ovalbumin (OA) with the adjuvant. Histopathological changes in the injection site and in some visceral organs were also examined. The observation periods after the injection for mice and rabbits were 20 and 28 weeks, respectively.<BR>In contrast to the most reports, FIA of both imperfectly emulsified-water-in-oil (W/O II) and oil-in-water (O/W) types were sometimes equivalent or superior to perfectly emulsified water-in-oil (W/O I) type FIA in the enhancing effects on precipitin formation both in rabbits and mice. The skin displayed the immediate type hypersensitivity reaction to OA throughout the observation period irrespective of the type of adjuvant. The O/W type often caused significantly stronger skin hyperreactivity than the other types.<BR>Histopathological findings in the injection site indicated that the abscess formation in rabbits was severer than that in mice, and that the O/W type induced the severest abscess. No relation was found between free fatty acid contents of adjuvant emulsion and abscess formation in either animal species. Granuloma formation in mice was always severer than that in rabbits. The O/W type caused extremely weak granuloma in mice, and none in rabbits. Histopathological changes in main visceral organs, being dependent on the emulsion type, were also discussed.
収録刊行物
-
- Japanese Journal of Medical Science and Biology
-
Japanese Journal of Medical Science and Biology 31 (1), 53-79, 1978
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206239309696
-
- NII論文ID
- 130003953258
- 40005305511
-
- NII書誌ID
- AA1132885X
-
- COI
- 1:STN:280:DyaE1c7pslCquw%3D%3D
-
- ISSN
- 18842828
- 00215112
-
- NDL書誌ID
- 1926951
-
- PubMed
- 661009
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可