EFFECT OF <I>N</I>- (3-PHENYL-2-PROPENYL) -1-DEOXYNOJIRIMYCIN ON THE LECTIN BINDING TO HIV-1 GLYCOPROTEINS
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- SHIMIZU Hiroyuki
- <I>AIDS Research Center, National Institute of Health</I>
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- TSUCHIE Hideaki
- <I>AIDS Research Center, National Institute of Health</I>
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- HONMA Hitoshi
- <I>AIDS Research Center, National Institute of Health</I>
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- YOSHIDA Kiyoshi
- <I>Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.</I>
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- TSURUOKA Takashi
- <I>Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.</I>
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- USHIJIMA Hiroshi
- <I>AIDS Research Center, National Institute of Health</I>
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- KITAMURA Takashi
- <I>AIDS Research Center, National Institute of Health</I>
Bibliographic Information
- Other Title
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- EFFECT OF N- (3-PHENYL-2-PROPENYL) -1-DEOXYNOJIRIMYCIN ON THE LECTIN BINDING TO HIV-1 GLYCOPROTEINS
Abstract
The effect of N- (3-phenyl-2-propenyl) -1-deoxynojirimycin (ppDNM) on the lectin binding to HIV-1 glycoprotein was analyzed by using biotinylated lectins of various sugar specificities as probes. ppDNM potentially inhibited HIV-1-induced syncytium formation and viral infectivity of HIV-1 without cytotoxicity. The lectin binding assay showed that ppDNM treatment reduced Con A binding to gp120 of HIV-1.
Journal
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- Japanese Journal of Medical Science and Biology
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Japanese Journal of Medical Science and Biology 43 (3), 75-87, 1990
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee