A Novel Complex Recombinant Form of Type 48-Related Human Adenovirus Species D Isolated in Japan
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- Fujimoto Tsuguto
- National Institute of Infectious Diseases
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- Yamane Shotaro
- Graduate School of Information Science and Technology, Hokkaido University
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- Ogawa Tomoko
- Chiba Prefectural Institute of Public Health
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- Hanaoka Nozomu
- National Institute of Infectious Diseases
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- Ogura Atsushi
- Chiba Prefectural Institute of Public Health
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- Hotta Chiemi
- Chiba Prefectural Institute of Public Health
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- Niwa Takeshi
- Chiba Prefectural Institute of Public Health
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- Chiba Yakou
- Nagayoshi Eye Clinic
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- Gonzalez Gabriel
- Graduate School of Information Science and Technology, Hokkaido University
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- Aoki Koki
- Department of Ophthalmology, Hokkaido University Graduate School of Medicine
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- Koyanagi Kanako Ono
- Graduate School of Information Science and Technology, Hokkaido University
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- Watanabe Hidemi
- Graduate School of Information Science and Technology, Hokkaido University
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抄録
Recently, new genotypes of human adenoviruses (HAdVs) have been reported and many of them have been found to be recombinant forms of different known types of HAdV species D (HAdV-D). The objective of this study was to document the evolutionary features of a novel isolate (HAdV_Chiba_E086/2012) obtained from the eye swab of a patient with conjunctivitis in Japan. Viral DNA was extracted from the isolate to sequence the whole genome by the Sanger method and aligned with available genome sequences of HAdV-Ds. The phylogenetic trees of the nucleotide sequences of the penton base, hexon, and fiber genes and the E3 region showed that HAdV_Chiba_E086/2012 is closest to HAdV genotype 65 (HAdV-GT65), HAdV-48, HAdV-GT60 and HAdV-22 at 98%, 99%, 95% and 98% identity, respectively, suggesting that this isolate is a novel recombinant form to be designated as P65H48F60. Further phylogenetic and recombination analyses of the genome alignment of the new isolate implied that nested recombination events involving HAdV-GT59, GT65, 48, GT60, 22, and some ancestral lineages or their close relatives have shaped its genome. These results showed that HAdV_Chiba_E086/2012 is the first HAdV-48-related HAdV found in Japan, which has the most complicated evolutionary history among the known HAdVs so far.
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 67 (4), 282-287, 2014
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001206239497856
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- NII論文ID
- 130004757096
- 130004692249
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 025606451
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- PubMed
- 25056074
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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