Genetic Analysis of HIV-1 in Japan: a Comprehensive Analysis of Donated Blood

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  • Matsumoto Chieko
    Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society
  • Shinohara Naoya
    Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society
  • Sobata Rieko
    Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society
  • Uchida Shigeharu
    Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society
  • Satake Masahiro
    Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society
  • Tadokoro Kenji
    Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society

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Abstract

In Japan, the number of human immunodeficiency virus (HIV)-1 infections remains relatively low; nevertheless, the annual incidence of HIV-1 infection has not decreased. New infections remain a great concern, and an improved understanding of epidemiological trends is critical for public health. The env C2V3 and pol sequences of HIV-1 RNA from 240 early (1996–2001) and 223 more recent (2010–2012) blood donations were used to compare the distribution of virus subtypes and to generate phylogenetic trees. Subtype B was clearly predominant in both early and more recent donations (both were 88.3%), and CRF01_AE was the second most common subtype. Phylogenetic analysis revealed a peculiar epidemiological transition. Compared to early subtype B isolates from 2 major endemic areas (Tokyo and Osaka), the more recent subtype B isolates formed fewer tight clusters in phylogenetic trees (from 8 to 2 clusters in Tokyo and 5 to zero clusters in Osaka). Furthermore, mixing of HIV-1 infections between these 2 endemic areas appear to increase. Analysis of phylogenetic trees suggested that local outbreaks have become smaller in Japan; however, intermixing of viral types between these 2 areas was more evident in the more recent samples.

Journal

  • Japanese Journal of Infectious Diseases

    Japanese Journal of Infectious Diseases 70 (2), 136-142, 2017

    National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

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