Human Parainfluenza Virus Type 3 Infections in Patients with Hematopoietic Stem Cell Transplants: the Mode of Nosocomial Infections and Prognosis

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  • Kakiuchi Satsuki
    Department of Virology 1, National Institute of Infectious Diseases Department of Developmental Medical Sciences, The University of Tokyo
  • Tsuji Masanori
    Department of Hematology, Toranomon Hospital
  • Nishimura Hidekazu
    Virus Research Center, Sendai Medical Center
  • Wang Lixing
    Department of Virology 1, National Institute of Infectious Diseases
  • Takayama-Ito Mutsuyo
    Department of Virology 1, National Institute of Infectious Diseases
  • Kinoshita Hitomi
    Department of Virology 1, National Institute of Infectious Diseases
  • Lim Chang-Kweng
    Department of Virology 1, National Institute of Infectious Diseases
  • Taniguchi Shuichi
    Department of Hematology, Toranomon Hospital
  • Oka Akira
    Department of Developmental Medical Sciences, The University of Tokyo
  • Mizuguchi Masashi
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
  • Saijo Masayuki
    Department of Virology 1, National Institute of Infectious Diseases Department of Pediatrics, Graduate School of Medicine, The University of Tokyo

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<p>There have been a few prospective and comprehensive surveillance studies on the respiratory viral infections (RVIs) among patients undergoing hematopoietic stem cell transplantation (HSCT). A 2-year prospective cohort surveillance study of symptomatic and asymptomatic RVIs was performed in hospitalized HSCT patients. Oropharyngeal (OP) swab samples were serially collected each week from 1 week before and up to 100 days after HSCT and were tested for virus isolation with cell culture-based viral isolation (CC-based VI) and a multiplex PCR (MPCR). A total of 2,747 OP swab samples were collected from 250 HSCT patients (268 HSCT procedures). Among these patients, 79 had RVIs (CC-based VI, n = 63; MPCR, n = 17). The parainfluenza virus type 3 (PIV3) accounted for 71% (57/80) of the cases of RVIs. Some PIV3 infections were asymptomatic and involved a longer virus-shedding period. The PIV3 was often cultured from samples taken before the onset of a respiratory disease. The PIV3 infections were attributed to the transmission of nosocomial infections. PIV3 infections before engraftment will more likely result in the development of lower respiratory tract infections and worse outcomes. A real-time monitoring of respiratory viral infections in the HSCT ward among patients with or without respiratory symptoms is required for the prevention of nosocomial RVIs, especially of PIV3 infections.</p>

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