Prevalence and Genotype Distribution of Chlamydia trachomatis in Urine among Men Attending Sexually Transmitted Disease Clinics in Guangdong Province, China, in 2016

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  • Xue Yaohua
    Department of Clinical Laboratory, Nanfang Hospital, Southern Medical University/ The First School of Clinical Medicine, Southern Medical University Department of Research Center, Dermatology Hospital, Southern Medical University/Guangdong Provincial Dermatology Hospital
  • Zheng Heping
    Department of Research Center, Dermatology Hospital, Southern Medical University/Guangdong Provincial Dermatology Hospital
  • Tang Weiming
    SESH Research Team at the School of Medicine, University of North Carolina at Chapel Hill Project-China
  • Mai Zhida
    Department of Research Center, Dermatology Hospital, Southern Medical University/Guangdong Provincial Dermatology Hospital
  • Huang Jinmei
    Department of Research Center, Dermatology Hospital, Southern Medical University/Guangdong Provincial Dermatology Hospital
  • Huang Shujie
    Department of Research Center, Dermatology Hospital, Southern Medical University/Guangdong Provincial Dermatology Hospital
  • Qin Xiaolin
    Department of Research Center, Dermatology Hospital, Southern Medical University/Guangdong Provincial Dermatology Hospital
  • Chen Lei
    Department of Research Center, Dermatology Hospital, Southern Medical University/Guangdong Provincial Dermatology Hospital
  • Zheng Lei
    Department of Clinical Laboratory, Nanfang Hospital, Southern Medical University/ The First School of Clinical Medicine, Southern Medical University

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  • Prevalence and Genotype Distribution of <i>Chlamydia trachomatis</i> in Urine among Men Attending Sexually Transmitted Disease Clinics in Guangdong Province, China, in 2016

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<p>Studies have rarely assessed the genotype distribution of Chlamydia trachomatis (CT) in urine among men attending sexually transmitted disease clinics (MSCs) in China. This study was aimed at investigating the prevalence and molecular epidemiology of CT infection by examining urine samples among MSCs from different geographic areas of Guangdong Province, China. A cross-sectional study was conducted among MSCs from 10 human immunodeficiency virus sentinel surveillance sites in Guangdong Province. CT DNA was extracted from male urine samples and analyzed using a Roche cobas 4800 CT/NG. The ompA genes were amplified by nested PCR and sequenced. The leukocyte esterase test was performed by routine urine analysis at local clinics. Of the 1,903 samples, 163 (8.6%, 95% confidence interval [CI] 3.8–16.3%) tested positive for CT. The highest prevalence (10.5%) of CT infection was observed among participants aged between 21 and 30 years. A total of 130 CT-positive samples (79.8%, 130/163) were successfully genotyped by nested PCR, resulting in 8 genotypes. The most prevalent genotypes were D, E, F, and J, with proportions of 20.8%, 20.0%, 17.7%, and 16.9%, respectively. There were no significant correlations between the geographical areas, leukocyte esterase test results and genotype distribution. Promotion of detection and molecular epidemiology research is needed for effective and comprehensive prevention and control programs.</p>

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