SURFACE CHARGE OF DENGUE VIRUS HEMAGGLUTININS PREPARED FROM INFECTED MOUSE BRAINS
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- INOUYE SAKAE
- <I>Central Virus Diagnostic Laboratory, National Institute of Health</I>
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- MATSUNO SHIGEO
- <I>Central Virus Diagnostic Laboratory, National Institute of Health</I>
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- HASEGAWA AYAKO
- <I>Central Virus Diagnostic Laboratory, National Institute of Health</I>
Bibliographic Information
- Other Title
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- Surface Charge of Dengue Virus Hemagglu
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Abstract
Surface charge of dengue virus hemagglutinin (HA) prepared from infected suckling mouse brains was studied by sucrose gradient electrophoresis. The findings were as follows: (1) Both the slow- and rapid-sedimenting hemagglutinins (SHA and RHA, respectively) prepared after streptomycin treatment of the brain homogenate were distributed broadly within the gradient after electrophoresis, while echovirus type 7 HA which was used as a reference migrated narrowly, sug-gesting heterogeneity of the surface charge of both dengue HAs. (2) Neuraminidase treatment of dengue HA slightly retarded its migration toward the anode but did not alter the broad distribution. (3) Protamine treatment used for purification of HA from the brain homogenate changed the surface charge from negative to positive.
Journal
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- Japanese Journal of Medical Science and Biology
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Japanese Journal of Medical Science and Biology 30 (2), 109-118, 1977
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
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Details 詳細情報について
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- CRID
- 1390001206240486656
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- NII Article ID
- 130003953250
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- NII Book ID
- AA1132885X
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- COI
- 1:CAS:528:DyaE2sXltlajtbk%3D
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- ISSN
- 18842828
- 00215112
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- NDL BIB ID
- 1819885
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- PubMed
- 916352
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed