The Antibacterial Effects of Antimicrobial Peptides OP-145 against Clinically Isolated Multi-Resistant Strains
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- Ming Liu
- Department of Respiratory, The First Affiliated Hospital of Suzhou University Department of Respiratory, Affiliated Hospital of Nanjing Medical University
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- Huang Jian-An
- Department of Respiratory, The First Affiliated Hospital of Suzhou University
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Description
<p>OP-145 is a synthetic antimicrobial peptide developed from the human cathelicidin LL-37. The purpose of this investigation was to evaluate the effect of the antimicrobial peptide OP-145 against clinically isolated drug-resistant strains. Ten methicillin-resistant Staphylococcus aureus (MRSA) strains were obtained from our hospital's clinical inspection center, and the activity of OP-145 on growth and biofilm formation of these strains was evaluated by colony counts and scanning electron microscopy. The antimicrobial peptide OP-145 showed significant antibacterial activity against 9 MRSA strains. For the biofilm experiments, MRSA counts in the biofilms decreased significantly after 24 h (P < 0.05). OP-145 strongly reduced growth and biofilm formation of clinically isolated drug-resistant strains in vitro, and the use of this class of antimicrobial agents may be an important new approach in controlling bacterial infections.</p>
Journal
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 70 (6), 601-603, 2017
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
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Details 詳細情報について
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- CRID
- 1390001206240564608
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- NII Article ID
- 130006210240
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- NII Book ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL BIB ID
- 028691546
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- PubMed
- 28890511
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed