Profile of Mutations in the Reverse Transcriptase and Overlapping Surface Genes of Hepatitis B Virus (HBV) in Treatment-Naive Indonesian HBV Carriers

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  • Yamani Laura Navika
    Institute of Tropical Disease, Airlangga University
  • Yano Yoshihiko
    Center for Infectious Diseases, Kobe University Graduate School of Medicine Department of Gastroenterology, Kobe University Graduate School of Medicine
  • Utsumi Takako
    Institute of Tropical Disease, Airlangga University Center for Infectious Diseases, Kobe University Graduate School of Medicine
  • Wasityastuti Widya
    Department of Physiology, Dr. Sardjito Hospital, Gadjah Mada University
  • Rinonce Hanggoro Tri
    Department of Anatomical Pathology, Faculty of Medicine, Dr. Sardjito Hospital, Gadjah Mada University
  • Widasari Dewiyani Indah
    Department of Anatomical Pathology, Faculty of Medicine, Dr. Sardjito Hospital, Gadjah Mada University
  • Juniastuti
    Institute of Tropical Disease, Airlangga University
  • Lusida Maria Inge
    Institute of Tropical Disease, Airlangga University
  • Soetjipto
    Institute of Tropical Disease, Airlangga University
  • Hayashi Yoshitake
    Center for Infectious Diseases, Kobe University Graduate School of Medicine

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  • Profile of Mutations in the Reverse Transcriptase and Overlapping Surface Genes of Hepatitis B Virus (HBV) in Treatment-Naïve Indonesian HBV Carriers

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<p>Mutations in the reverse transcriptase (RT) region of the hepatitis B virus (HBV) genome are an important factor in low therapeutic effectiveness. Nonetheless, the prevalence of these mutations in HBV strains isolated previously in Indonesia has not been systematically examined. Therefore, in this study, we investigated the profile of mutations in the RT region and the associations of these mutations with amino acid changes in the surface protein in the virus of treatment-naïve Indonesian HBV carriers. Overall, 96 sequences of the full-length Indonesian HBV genomes (genotype B, n = 54; genotype C, n = 42) were retrieved from the National Center for Biotechnology Information. Naturally occurring primary and/or compensatory drug resistance mutations were found in 6/54 (11.1%) genotype B strains and in 1/42 (2.4%) genotype C strains. The potential mutations underlying resistance to a nucleos(t)ide analog and/or pretreatment mutations were more frequent in both genotypes but more frequent in genotype C strains than in genotype B strains. The A–B interdomain region in the RT gene was more frequently mutated in genotype C than in genotype B (3.51 ± 2.53 vs. 1.08 ± 1.52, P ＜ 0.001). Knowledge about the mutational profiles of the RT gene and changes in the surface protein may help clinicians to select the most appropriate antiviral drug and vaccination or HBV immunoglobulin regimen for management of HBV infection in Indonesia.</p>

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