An Alarmingly High Proportion of HIV-1 Isolates Carrying Mutations Corresponding to Resistance to Antiretroviral Drugs among HIV-Positive High-Risk Groups in Central Vietnam: a Substudy of the National Sentinel Survey
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- Do Hung Thai
- Pasteur Institute in Nha Trang Institute of Tropical Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki University
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- Nguyen Dong Thanh
- Pasteur Institute in Nha Trang
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- Nguyen Lan Anh Thi
- National Institute of Hygiene and Epidemiology
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- Do Duong Huy
- National Institute of Hygiene and Epidemiology
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- Le Huy Xuan
- Pasteur Institute in Nha Trang
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- Trinh Xuan Mai Thi
- Pasteur Institute in Nha Trang
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- Ton Hong Vy Nu
- Pasteur Institute in Nha Trang
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- Sawada Ikumi
- Institute of Tropical Medicine, Nagasaki University
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- Kitamura Noriko
- Institute of Tropical Medicine, Nagasaki University
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- Le Minh Nhat
- Institute of Tropical Medicine, Nagasaki University
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- Yoshihara Keisuke
- Institute of Tropical Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki University
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- Phan Thu Huong Thi
- Vietnam Administration of HIV/AIDS Control, Ministry of Health
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- Bui Chien Trong
- Pasteur Institute in Nha Trang
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- Ariyoshi Koya
- Institute of Tropical Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki University
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- Yoshida Lay Myint
- Institute of Tropical Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki University
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<p>We studied the prevalence of HIV drug resistance among high-risk groups such as injecting drug users (IDUs), female sex workers (FSWs), and men having sex with men (MSM) in central Vietnam. We used HIV-positive blood samples from 2012–2013 sentinel surveillance surveys. Study subjects were screened for HIV infection by standardized screening assays, and the HIV-positive samples were further tested for HIV viral load and drug-resistance mutations (DRMs) by in-house assays. DRMs were identified using the Stanford University online sequence analysis tool. Their risk behaviors were also investigated. During the study period, 6,016 (high-risk) subjects were screened, and 97 tested positive for HIV infection (IDUs: n = 63, 3.0%; FSWs: n = 24, 0.9%; and MSM: n = 10, 1.0%). Ninety-two of the 97 samples (45 from 2012 and 47 from 2013) were available for further testing. HIV RNA was detected in 56 (60.9%) of the 92 samples, and drug resistance genotyping was successfully performed on 40 (71.4%) samples. All these isolates were subtype CRF01_AE, except for 1 (2.5%) IDU whose HIV belongs to subtype B. Thirteen individuals (32.5%) were carrying HIV with at least 1 DRM: 9 IDUs, 1 FSW, and 3 MSM. Thus, HIV seroprevalence among high-risk individuals in central Vietnam is low, but a high proportion of drug resistant HIV-1 isolates is observed in the high-risk group.</p>
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 70 (6), 621-627, 2017
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001206240583040
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- NII論文ID
- 130006210254
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- HANDLE
- 10069/37943
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- NDL書誌ID
- 028691615
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- PubMed
- 28890504
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- 本文言語コード
- en
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- IRDB
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