Molecular Analysis of Ciprofloxacin Resistance among Non-Typhoidal Salmonella with Reduced Susceptibility to Ciprofloxacin Isolated from Patients at a Tertiary Care Hospital in Kuala Lumpur, Malaysia
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- Karunakaran Rina
- Department of Medical Microbiology, Faculty of Medicine, University of Malaya
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- Tay Sun Tee
- Department of Medical Microbiology, Faculty of Medicine, University of Malaya
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- Rahim Fairuz Fadzilah
- Department of Medical Microbiology, Faculty of Medicine, University of Malaya
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- Lim Bee Bee
- Department of Medical Microbiology, Faculty of Medicine, University of Malaya
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- Puthucheary Savithri D.
- Department of Medical Microbiology, Faculty of Medicine, University of Malaya Medical Education, Research and Evaluation Department, Duke-NUS Graduate Medical School Singapore
書誌事項
- タイトル別名
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- Molecular Analysis of Ciprofloxacin Resistance among Non-Typhoidal <i>Salmonella</i> with Reduced Susceptibility to Ciprofloxacin Isolated from Patients at a Tertiary Care Hospital in Kuala Lumpur, Malaysia
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We investigated the prevalence of non-typhoidal Salmonella (NTS) with “reduced susceptibility to ciprofloxacin” (RS-Cip) (minimum inhibitory concentration [MIC], 0.12–1.0 μg/mL) as well as their resistance genes in 75 NTS isolates (53 from stool, 21 from blood, and 1 from urine) from patients at a tertiary care Malaysian hospital between January and December 2009. RS-Cip was detected in 24/75 (32.0%) isolates. Using the ciprofloxacin MIC interpretive criteria for Salmonella in the Clinical and Laboratory Standards Institute 2013 guidelines, 51/75 (68.0%) isolates were found to be sensitive, 22/75 (29.3%) were intermediate, and 2/75 (2.7%) were resistant to ciprofloxacin. The 24 isolates that were intermediate or resistant to ciprofloxacin were the same isolates categorized as having RS-Cip. Among the 23 tested isolates with RS-Cip, the qnrS gene was detected in 17/23 (73.9%) and single gyrA mutations were detected in 6/23 (26.1%) (Asp87Tyr [n = 3], Asp87Asn [n = 2], and Ser83Phe [n = 1]). A parC (Thr57Ser) mutation was detected in 13/23 (56.5%) isolates, coexisting with either a qnrS gene or a gyrA mutation. The high incidence of the qnrS gene among isolates with RS-Cip needs to be monitored because qnr genes can spread via plasmids and aid in the emergence of increased resistance levels.
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 67 (3), 157-162, 2014
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001206240929280
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- NII論文ID
- 130004757075
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 025476312
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- PubMed
- 24858603
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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