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PRODUCTION AND CHARACTERIZATION OF ANTIBODIES TO OUABAIN
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- TERANO Yoshitake
- <I>Department of Physiology, Osaka City University Medical School</I>
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- TOMII Akiko
- <I>Department of Geriatrics, Osaka University Medical School</I>
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- MASUGI Fuminori
- <I>Department of Geriatrics, Osaka University Medical School</I>
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Description
Two monoclonal antibodies (249F8 and 278A9) to ouabain were produced by somatic cell fusion. They reacted in dose-dependent manners with ouabain and digoxin. These antibodies were supposed to recognize the partial structure important for cardiac compounds to show their pharmacological activity, Na+, K+-ATPase inhibition in a competitive mode against K+. These monoclonal antibodies may be useful for the immunochemical isolation, the structual elucidation, and the quantitative measurement of putative endogeneous digoxin-like factors.
Journal
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- Japanese Journal of Medical Science and Biology
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Japanese Journal of Medical Science and Biology 44 (3), 123-139, 1991
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
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Keywords
Details 詳細情報について
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- CRID
- 1390001206240985856
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- NII Article ID
- 130003953446
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- COI
- 1:CAS:528:DyaK38Xitlent70%3D
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- ISSN
- 18842828
- 00215112
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- PubMed
- 1664470
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed