Isolation and Characterization of an <i>Escherichia albertii</i> Strain Producing Three Different Toxins from a Child with Diarrhea

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  • Hinenoya Atsushi
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • Yasuda Noritomo
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • Hibino Takumi
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • Shima Ayaka
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • Nagita Akira
    Department of Pediatrics, Mizushima General Hospital
  • Tsukamoto Teizo
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • Yamasaki Shinji
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University

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Other Title
  • Isolation and Characterization of an Escherichia albertii Strain Producing Three Different Toxins from a Child with Diarrhea
  • Isolation and characterization of an Escherichia albertii producing three different toxins isolated from a child with diarrhea

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Abstract

<p>Here, we report a bacterium—isolated as the sole pathogen from a child with diarrhea—harboring eae and 2 different cytolethal distending toxin genes (cdt) that are homologous to Escherichia coli cdt-I and cdt-II. The bacterium was originally identified as atypical E. coli by conventional biochemical testing, but was finally identified as E. albertii by multilocus sequence analysis, which is the only method that can currently differentiate E. albertii from E. coli. The Shiga toxin 2f (stx2f) genes were also detected in the strain. Production of these 3 toxins was confirmed by western blotting and/or a cytotoxicity assay using eukaryotic cell lines. This is the first report showing the biological activity of CDT-I, CDT-II, and Stx2f in E. albertii.</p>

Journal

  • Japanese Journal of Infectious Diseases

    Japanese Journal of Infectious Diseases 70 (3), 252-257, 2017

    National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

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