Clinical and Diagnostic Aspects of Brucellosis and Antimicrobial Susceptibility of Brucella Isolates in Hamedan, Iran
-
- Torkaman Asadi Fatemeh
- Brucellosis Research Center, Hamedan University of Medical Sciences Blood Transfusion Research Center, High Institute for Research; Education in Transfusion
-
- Hashemi Seyyed Hamid
- Brucellosis Research Center, Hamedan University of Medical Sciences Division of Infectious Diseases, Sina Hospital
-
- Alikhani Mohammad Yousef
- Brucellosis Research Center, Hamedan University of Medical Sciences
-
- Moghimbeigi Abbas
- Brucellosis Research Center, Hamedan University of Medical Sciences
-
- Naseri Zahra
- Blood Transfusion Research Center, High Institute for Research; Education in Transfusion
書誌事項
- タイトル別名
-
- Clinical and Diagnostic Aspects of Brucellosis and Antimicrobial Susceptibility of <i>Brucella</i> Isolates in Hamedan, Iran
この論文をさがす
抄録
<p>Current drug regimens for brucellosis are associated with relatively high rates of therapeutic failure or relapse. Reduced antimicrobial susceptibility of Brucella spp. has been proposed recently as a potential cause of therapeutic failure. The aim of this study was to evaluate the antibiotic resistance pattern of Brucella melitensis clinical isolates by E-test method in Hamadan, west of Iran. In a 15-month period, all patients with suspected brucellosis were enrolled. Blood specimens were collected for diagnosis of brucellosis by BACTEC system and serological tests. Antimicrobial susceptibility of clinical isolates to 7 antibiotics was assessed by the E-test method. One hundred forty-nine patients with brucellosis were evaluated. 38.3% of cultures of clinical samples were positive for BACTEC system, of which 91.2% were associated with a positive serological test result. No significant associations were found between serology and the culture method. All Brucella isolates were susceptible to doxycycline, streptomycin, gentamicin, ciprofloxacin, and moxifloxacin. However, decreased sensitivity to rifampin and trimethoprim-sulfamethoxazole was found in 35.1% and 3.5% of isolates, respectively. Because of the high rates of intermediate sensitivity to rifampin among Brucella isolates, this drug should be prescribed with caution. We recommend restricting the use of rifampin for treatment of brucellosis except as an alternative drug for special situations. </p>
収録刊行物
-
- Japanese Journal of Infectious Diseases
-
Japanese Journal of Infectious Diseases 70 (3), 235-238, 2017
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001206241132416
-
- NII論文ID
- 130005671843
-
- NII書誌ID
- AA1132885X
-
- ISSN
- 18842836
- 13446304
-
- NDL書誌ID
- 028198141
-
- PubMed
- 27580575
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可