Outbreak of Multiresistant OXA-24- and OXA-51-Producing Acinetobacter baumannii in an Internal Medicine Ward

  • Tena Daniel
    Sección de Microbiología, Hospital Universitario de Guadalajara
  • Martínez Nora Mariela
    Sección de Microbiología, Hospital Universitario de Guadalajara
  • Oteo Jesús
    Laboratorio de Antibióticos, Servicio de Bacteriología, CNM
  • Sáez David
    Laboratorio de Antibióticos, Servicio de Bacteriología, CNM
  • Vindel Ana
    Laboratorio de Infecciones Intrahospitalarias, Servicio de Bacteriología, CNM
  • Azañedo María Luisa
    Laboratorio de Infecciones Intrahospitalarias, Servicio de Bacteriología, CNM
  • Sánchez Lorenzo
    Servicio de Medicina Interna, Hospital Universitario de Guadalajara
  • Espinosa Alfredo
    Servicio de Medicina Interna, Hospital Universitario de Guadalajara
  • Cobos Juan
    Servicio de Medicina Preventiva, Hospital Universitario de Guadalajara
  • Sánchez Rosario
    Servicio de Medicina Preventiva, Hospital Universitario de Guadalajara
  • Otero Ignacio
    Servicio de Urología, Hospital Universitario de Guadalajara
  • Bisquert Julia
    Sección de Microbiología, Hospital Universitario de Guadalajara

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  • Outbreak of Multiresistant OXA-24- and OXA-51-Producing <i>Acinetobacter baumannii</i> in an Internal Medicine Ward

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Here we describe the clinical, microbiological, epidemiological, and molecular characterization of an outbreak of multidrug-resistant Acinetobacter baumannii (MRAB) involving 5 patients admitted to the internal medicine ward of our hospital. Over a 6-week period, 5 MRAB isolates were recovered from 5 patients, including 1 with fatal meningitis, 3 with skin and soft tissue infections, and 1 with respiratory colonization. One sample obtained during environmental monitoring in the ward was A. baumannii-positive. According to the pulsed-field gel electrophoresis typing results, the strains isolated from all patients and the environmental sample belonged to a single clone, identified as ST79 by multilocus sequence typing. The blaOXA-24 and blaOXA-51 carbapenemases were detected in all isolates. Four patients died, but only the death of the meningitis patient was probably related to the A. baumannii infection. The infection source was probably the hands of the healthcare workers because the outbreak strain was isolated from the surface of a serum container. The results of the present study revealed the importance of strict adherence to control measures by all healthcare workers because the consequences of noncompliance can be very serious.

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