Changes in Streptococcus pneumoniae Serotypes in the Nasopharynx of Japanese Children after Inoculation with a Heptavalent Pneumococcal Conjugate Vaccine

DOI Web Site PubMed 参考文献11件 オープンアクセス
  • Ueno Masahiro
    Department of Pediatrics, Hasuda Issinkai Hospital Department of Environmental and Occupational Health, School of Medicine, Toho University
  • Ishii Yoshikazu
    Department of Microbiology and Infectious Diseases, School of Medicine, Toho University
  • Tateda Kazuhiro
    Department of Microbiology and Infectious Diseases, School of Medicine, Toho University
  • Anahara Yoshiko
    Department of Bacteriology, Ageo Medical Laboratories, Inc.
  • Ebata Akiko
    Department of Bacteriology, Ageo Medical Laboratories, Inc.
  • Iida Masaei
    Department of Bacteriology, Ageo Medical Laboratories, Inc.
  • Mizuno Fumie
    Department of Otorhinolaryngology, Hasuda Issinkai Hospital
  • Inamura Seiko
    Yashio Ekimae Internal Medicine and Pediatric Clinic
  • Takahata Kaori
    Department of Pediatrics, Tokyo Women's Medical University Medical Center East
  • Suzuki Yoko
    Department of Pediatrics, Tokyo Women's Medical University Medical Center East
  • Chang Bin
    Department of Bacteriology I, National Institute of Infectious Diseases
  • Wada Akihito
    Department of Bacteriology I, National Institute of Infectious Diseases Yonaguni Medical Clinic
  • Sugita Minoru
    Department of Environmental and Occupational Health, School of Medicine, Toho University
  • Tanaka Taichiro
    Department of Environmental and Occupational Health, School of Medicine, Toho University
  • Nishiwaki Yuji
    Department of Environmental and Occupational Health, School of Medicine, Toho University

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タイトル別名
  • Changes in <i>Streptococcus pneumoniae</i> Serotypes in the Nasopharynx of Japanese Children after Inoculation with a Heptavalent Pneumococcal Conjugate Vaccine

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説明

In this study, we prospectively investigated changes in Streptococcus pneumoniae serotypes among Japanese children after heptavalent pneumococcal conjugate vaccine (PCV7) inoculation. We acquired nasopharyngeal swabs from the children at each routine PCV7 inoculation and again at least 2 months after the last PCV7 inoculation. We defined 2 periods with regard to each culture: the inoculation period as “the period of pre- or incomplete vaccination” and post-inoculation as “the period of post- or completed vaccination.” The prevalence of vaccine-type (VT) pneumococci was significantly reduced from 9.5% in the inoculation-period cultures to 2.9% in the post-inoculation cultures (P < 0.01). There was no statistical difference in the prevalence of non-vaccine-type pneumococci between the inoculation-period and post-inoculation cultures (24.1% versus 23.4%). The protection of PCV7 against nasopharyngeal colonization was inferred from the decrease in VT carriage post-inoculation. The decrease in VT carriage may be conducive to reducing VT transmission within the study area.

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