Osteopontin Exacerbates Pulmonary Damage in Influenza-Induced Lung Injury
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- Zhu Yunan
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases
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- Wei Yingfeng
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases
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- Chen Jianing
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases
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- Cui Guangying
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases
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- Ding Yulong
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases
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- Kohanawa Masashi
- Department of Microbiology, School of Medicine, Hokkaido University
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- Xu Xuejun
- Department of Oral Orthodontics, Affiliated Stomatology Hospital, School of Medicine, Zhejiang University
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- Diao Hongyan
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases
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抄録
The level of osteopontin (OPN) increases during bacterial lung infection. However, the OPN level in virus-induced lung injury is unclear, and the relationship between the hyer-production of OPN and lung injury remains to be thoroughly understood. Therefore, we sought to determine whether a relationship exists between OPN and pulmonary damage. Particularly, pulmonary edema and the destruction of pulmonary tissue. In this study, we found that the OPN level was significantly elevated in patients with pulmonary damage, and there was a positive correlation between the OPN serum level and disease severity in influenza lung injury. The epithelial sodium channel (ENaC) is the main mechanism of clearance of pulmonary edema fluid, and matrix metalloproteinase 7 (MMP7) can degrade the extracellular matrix. In lung epithelial cells, OPN markedly decreased the mRNA expression of the α-subunit of ENaC through integrin β3 and CD44 (OPN receptors); however, the expression of MMP7 was promoted by OPN interaction with integrin β1 and CD44. In addition, OPN increased the levels of tumor necrosis factor-α and interleukin-6. These findings suggested that OPN might increase influenza virus-induced lung injury by augmenting lung epithelial cell apoptosis and impairing ENaC and extracellular matrix destruction.
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 68 (6), 467-473, 2015
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001206241238912
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- NII論文ID
- 130005109793
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 026947428
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- PubMed
- 25866117
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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