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- Naka Izumi
- Faculty of Medicine, University of Tsukuba
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- Patarapotikul Jintana
- Faculty of Tropical Medicine, Mahidol University
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- Hananantachai Hathairad
- Faculty of Tropical Medicine, Mahidol University
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- Ohashi Jun
- Faculty of Medicine, University of Tsukuba
書誌事項
- タイトル別名
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- Lack of Association between <i>BSG</i> Polymorphisms and Cerebral Malaria
この論文をさがす
抄録
The Oka blood group antigen basigin (BSG or CD147) is an erythrocyte receptor for the PfRh5 protein from Plasmodium falciparum. A recent study has shown that the PfRh5–BSG interaction is essential for erythrocyte invasion by P. falciparum. In this study, 6 SNPs in the BSG gene were investigated in 312 adult patients with P. falciparum malaria (109 cerebral malaria and 203 mild malaria patients) living in northwest Thailand. To examine the association between BSG SNPs and cerebral malaria, the allele and haplotype frequencies were compared in cerebral and mild malaria patients. Nonsynonymous SNPs were not assessed in the association analysis. The results showed that common BSG polymorphisms and haplotypes were not significantly associated with cerebral malaria. In conclusion, common SNPs in BSG do not influence the risk of cerebral malaria in the Thai population.
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 67 (6), 432-435, 2014
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001206241527296
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- NII論文ID
- 130004712734
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 025937801
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- PubMed
- 25410557
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可