Chlorine Dioxide is a Better Disinfectant than Sodium Hypochlorite against Multi-Drug Resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Acinetobacter baumannii
-
- Hinenoya Atsushi
- Graduate School of Life and Environmental Sciences, Osaka Prefecture University
-
- Awasthi Sharda Prasad
- Graduate School of Life and Environmental Sciences, Osaka Prefecture University
-
- Yasuda Noritomo
- Graduate School of Life and Environmental Sciences, Osaka Prefecture University
-
- Shima Ayaka
- Graduate School of Life and Environmental Sciences, Osaka Prefecture University
-
- Morino Hirofumi
- Taiko Pharmaceutical Co., Ltd.
-
- Koizumi Tomoko
- Taiko Pharmaceutical Co., Ltd.
-
- Fukuda Toshiaki
- Taiko Pharmaceutical Co., Ltd.
-
- Miura Takanori
- Taiko Pharmaceutical Co., Ltd.
-
- Shibata Takashi
- Taiko Pharmaceutical Co., Ltd.
-
- Yamasaki Shinji
- Graduate School of Life and Environmental Sciences, Osaka Prefecture University
書誌事項
- タイトル別名
-
- Chlorine Dioxide is a Better Disinfectant than Sodium Hypochlorite against Multi-Drug Resistant <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Acinetobacter baumannii</i>
この論文をさがす
抄録
In this study, we evaluated and compared the antibacterial activity of chlorine dioxide (ClO2) and sodium hypochlorite (NaClO) on various multidrug-resistant strains in the presence of bovine serum albumin and sheep erythrocytes to mimic the blood contamination that frequently occurs in the clinical setting. The 3 most important species that cause nosocomial infections, i.e., methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Pseudomonas aeruginosa (MDRP), and multidrug-resistant Acinetobacter baumannii (MDRA), were evaluated, with three representative strains of each. At a 10-ppm concentration, ClO2 drastically reduced the number of bacteria of all MDRP and MDRA strains, and 2 out of 3 MRSA strains. However, 10 ppm of NaClO did not significantly kill any of the 9 strains tested in 60 seconds (s). In addition, 100 ppm of ClO2 completely killed all MRSA strains, whereas 100 ppm of NaClO failed to significantly lower the number of 2 MRSA strains and 1 MDRA strain. A time-course experiment demonstrated that, within 15 s, 100 ppm of ClO2, but not 100 ppm of NaClO, completely killed all tested strains. Taken together, these data suggest that ClO2 is more effective than NaClO against MRSA, MDRP, and MDRA, and 100 ppm is an effective concentration against these multidrug-resistant strains, which cause fatal nosocomial infections.
収録刊行物
-
- Japanese Journal of Infectious Diseases
-
Japanese Journal of Infectious Diseases 68 (4), 276-279, 2015
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206241896320
-
- NII論文ID
- 130005088795
-
- NII書誌ID
- AA1132885X
-
- ISSN
- 18842836
- 13446304
-
- NDL書誌ID
- 026618238
-
- PubMed
- 25672403
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可