TUMOR IMMUNITY INDUCED BY BCG-TUMOR CELL MIXTURES IN SYNGENEIC MICE
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- TOKUNAGA TOHRU
- <I>Department of Tuberculosis, National Institute of Health</I>
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- KATAOKA TETSURO
- <I>Department of Tuberculosis, National Institute of Health</I>
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- NAKAMURA REIKO M.
- <I>Department of Tuberculosis, National Institute of Health</I>
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- YAMAMOTO SABURO
- <I>Department of Tuberculosis, National Institute of Health</I>
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- TANAKA TOMIKO
- <I>National Cancer Center Research Institute</I>
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Abstract
Effects of mixing living BCG with living tumor cells on the growth of the tumor cells in the intradermally inoculated mice and induction of the tumor immunity were investigated with various syngeneic and allogeneic mouse tumor systems. Tumor immunity was assessed from transplant resistance against challenge tumor grafts, macrophage migration inhibition and peritoneal macrophage disappearance. The effects of BCG-tumor cell mixtures varied depending upon the tumor lines and also upon the experimental conditions employed. From the modes of the effect, the tumors used were classified into the following three types: (1) rejecting the primary tumor grafts and inducing the tumor-specific, cell-mediated immunity; (2) rejecting the primary tumor grafts but inducing no detectable tumor immunity; and (3) not rejecting the primary tumor grafts even in BCG-sensitized mice. These types seemed to correlate with the levels of antigenicity and the growth rates of the tumor cells. Number of the tumor cells in the inoculum, in addition to the tumor lines, largely influenced the effects. For the optimal suppression of the growth of tumor cells in the primary inocula, generally required were the following factors : (1) prior sensitization of mice to BCG, (2) direct contact between BCG and tumor cells, and (3) intradermal route of injection.
Journal
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- Japanese Journal of Medical Science and Biology
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Japanese Journal of Medical Science and Biology 26 (2), 71-85, 1973
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
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Details 詳細情報について
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- CRID
- 1390001206241944448
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- NII Article ID
- 130003778284
- 40018679677
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- NII Book ID
- AA1132885X
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- COI
- 1:STN:280:CSuD3svptlw%3D
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- ISSN
- 18842828
- 00215112
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- NDL BIB ID
- 7672161
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- PubMed
- 4585343
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed