Molecular Epidemiology of Methicillin-Resistant <i>Staphylococcus aureus</i> Isolated from Children in a Community with Low Antimicrobial Pressure in Japan
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- Otsuka Taketo
- Department of Pediatrics, Sado General Hospital
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- Zaraket Hassan
- Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital
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- Fujii Koyata
- Department of Pediatrics, Sado General Hospital
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- Masuda Yasuko
- Department of Clinical Laboratory, Sado General Hospital
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- Komiyama Kenichi
- Department of Clinical Laboratory, Sado General Hospital
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- Ishikawa Yukio
- Department of Clinical Laboratory, Sado General Hospital
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- Shirai Takatoshi
- Department of Pediatrics, Ryotsu Hospital
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- Iwaya Atsushi
- Department of Pediatrics, Ryotsu Hospital
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- Okazaki Minoru
- Department of Pediatrics, Sado General Hospital
Bibliographic Information
- Other Title
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- Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Isolated from Children in a Community with Low Antimicrobial Pressure in Japan
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Abstract
Sado Island in Japan is an area with low antimicrobial pressure. A total of 41 community-onset methicillin-resistant Staphylococcus aureus (MRSA) isolates were obtained from pediatric outpatients and healthy children between August 2009 and January 2012, and genotyping and antimicrobial susceptibility testing of the MRSA isolates were performed. Additionally, the sources of MRSA isolated from healthy 1-month-old neonates were assessed. All isolates were negative for the Panton-Valentine leukocidin genes. Our data showed a lower prevalence of staphylococcal cassette chromosome (SCC)mecII on Sado Island (31.7% in total and 46.7% in healthy carriage) than that in the other areas of Japan, suggesting that a low level of antimicrobial use may be related to a low SCCmecII carriage rate in the community. To our knowledge, this is the first report of sequence type (ST)81/SCCmecIVg strains as well as the novel ST strain (ST2180/SCCmecIVa) in Japan. In addition, we detected an arginine catabolic mobile element (ACME)-arcA-positive ST764/SCCmecIIa clone that could disseminate successfully in the community. Intrafamilial transmission was observed in neonates identified with the SCCmecIV MRSA strains, and these strains were genetically typed as community-associated MRSA; the transmission routes of the remaining SCCmecIIa MRSA (genetically typed as healthcare-associated MRSA) strains could not be defined. In this study, we have shown that multiple MRSA strains can circulate in a community even under low antimicrobial pressure.
Journal
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 65 (6), 483-488, 2012
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
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Details 詳細情報について
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- CRID
- 1390001206242031488
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- NII Article ID
- 130002588755
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- NII Book ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL BIB ID
- 024104855
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- PubMed
- 23183199
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed
