Evolution of Plasmodium falciparum drug resistance : implications for the development and containment of artemisinin resistance
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- Mita Toshihiro
- Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine Department of International Affairs and Tropical Medicine, Tokyo Women's Medical University
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- Tanabe Kazuyuki
- Laboratory of Malariology, Research Institute for Microbial Diseases, Osaka University Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University
書誌事項
- タイトル別名
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- Evolution of <i>Plasmodium falciparum</i> drug resistance: implications for the development and containment of artemisinin resistance
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抄録
Malaria is a protozoan disease transmitted by the bite of the Anopheles mosquito. Among five species that can infect humans, Plasmodium falciparum is responsible for the most severe human malaria. Resistance of P. falciparum to chloroquine and pyrimethamine/sulfadoxine, conventionally used antimalarial drugs, is already widely distributed in many endemic areas. As a result, artemisinin-based combination therapies have been rapidly and widely adopted as first-line antimalarial treatments since the mid-2000s. Recent population and evolutionary genetic analyses have proven that the geographic origins of parasite lineages resistant to the conventional drugs are considerably limited. Almost all resistance emerged from either Southeast Asia or South America. The Greater Mekong subregion in Southeast Asia is probably the most alarming source of resistance, from which P. falciparum resistant to chloroquine and pyrimethamine/sulfadoxine dispersed to Africa. The emergence of artemisinin resistance has also recently been confirmed in the Greater Mekong. The WHO Global Malaria Programme has recently launched a “Global Plan for Artemisinin Resistance Containment,” which aims to prevent the spread of artemisinin resistance while also stopping the emergence of novel resistance. However, an inadequate understanding of a mechanism of artemisinin resistance and the lack of reliable genetic markers to monitor artemisinin resistance make it difficult to survey the spread of resistance. Elucidation of such markers would substantially contribute to the design of an effective policy for the containment of artemisinin resistance.
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 65 (6), 465-475, 2012
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001206242033536
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- NII論文ID
- 130002588753
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 024104827
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- PubMed
- 23183197
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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