Evaluation of somatic and "ES" antigens causing immunological injury of mast cells in mice infected with Anisakis larvae
書誌事項
- タイトル別名
-
- EVALUATION OF SOMATIC AND “ES” ANTIGENS CAUSING IMMUNOLOGICAL INJURY OF MAST CELLS IN MICE INFECTED WITH <I>ANISAKIS</I> LARVAE
- EVALUATION OF SOMATIC AND ^|^ldquo;ES^|^rdquo; ANTIGENS CAUSING IMMUNOLOGICAL INJURY OF MAST CELLS IN MICE INFECTED WITH ANISAKIS LARVAE
この論文をさがす
抄録
The worm extract (somatic antigen) and exsheathing fluid (“ES”antigen) derived from Anisakis larvae were tested and evaluated as antigen for detecting hypersensitivity in the infected mice. Heterologous antigens from Toxocara canis and Ascaris suum were also tested for comparison.<BR>Mice were infected intraperitoneally each with 5 living Anisakis larvae. Subcutaneous air pouches were made on these mice at various intervals after infection and their spreads were studied for mast cell degranulation after injections of the antigens.<BR>Anisakis antigens, both “ES” and somatic, produced more marked damages to the cells than the heterologous antigens. The host-tissue sensitivity to “ES” antigen appeared 10 days after infection with the larvae and persisted for at least 6 months, showing maximal rates of cell damage (97.7%) 2 months after infection.<BR>The “ES” antigen produced much more intensive damages to the cells than the somatic antigen at both early and late stages in the course of infection, with the most conspicuous difference a month after infection.<BR>In another test with mice infected with Ascaris suum eggs, Ascaris antigen gave more marked cell damages than Anisakis and Toxocara antigens.<BR>Discussions were made in relation to the superiority of “ES” over somatic antigen in the skin test for human anisakiasis, particularly at an early stage of the infection.
収録刊行物
-
- Japanese Journal of Medical Science and Biology
-
Japanese Journal of Medical Science and Biology 25 (5), 335-344, 1972
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206242040448
-
- NII論文ID
- 130003778277
- 40018679650
-
- NII書誌ID
- AA1132885X
-
- COI
- 1:STN:280:DyaE3s7ms1Ohug%3D%3D
-
- ISSN
- 18842828
- 00215112
-
- NDL書誌ID
- 7672134
-
- PubMed
- 4540718
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可