RESPONSE OF TYPE B AND E BOTULINUM TOXINS TO PURIFIED SULFHYDRYL-DEPENDENT PROTEASE PRODUCED BY<I> CLOSTRIDIUM BOTULINUM</I> TYPE F

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  • OHISHI IWAO
    <I>College of Agriculture, University of Osaka Prefecture</I>
  • SAKAGUCHI GENJI
    <I>College of Agriculture, University of Osaka Prefecture</I>

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Other Title
  • Response of Type B and E Botulinum Toxins to Purified Sulfhydryl-Dependent Protease Produced by Clostridum Botulinum Type F
  • Response of Type B and E Botulinum Toxi
  • RESPONSE OF TYPE B AND E BOTULINUM TOXINS TO PURIFIED SULFHYDRYL-DEPENDENT PROTEASE PRODUCED BY CLOSTRIDIUM BOTULINUM TYPE F

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A sulfhydryl-dependent protease (SHP) was purified from a culture ofClostridium botulinumtype F. The enzyme can activate type E progenitor toxin completely but type B progenitor toxin only partially. This may suggest that SHP by itself could completely activate the toxin of proteolyticC. botulinumtypes A and F in culture. The toxicity of type E progenitor toxin potentiated by the treatment with SHP persisted, whereas that of derivative toxin decreased rapidly by further incubation with SHP. This may indicate that only the progenitor toxin, the complex of the toxic and nontoxic components, activated by SHP withstands the subsequent exposure to the enzyme in cultures of proteolyticC. botulinum.

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