Increased Irisin Concentrations in Patients with Crimean- Congo Hemorrhagic Fever
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- Büyüktuna Seyit Ali
- Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, University of Cumhuriyet
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- Doğan Halef Okan
- Department of Biochemistry, Faculty of Medicine, University of Cumhuriyet
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- Bakır Deniz
- Department of Biochemistry, Faculty of Medicine, University of Cumhuriyet
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- Erşan Serpil
- Department of Biochemistry, Faculty of Medicine, University of Cumhuriyet
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- Koç Derya
- Department of Biochemistry, Faculty of Medicine, University of Cumhuriyet
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- Bakır Sevtap
- Department of Biochemistry, Faculty of Medicine, University of Cumhuriyet
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<p>Crimean-Congo Hemorrhagic Fever (CCHF) is a life-threatening viral infection. The pathogenesis of the disease is not well understood. The aim of this study was to determine the change in irisin concentrations in patients with CCHF. The study included a total of 30 patients with CCHF and 30 control participants. Irisin concentrations were determined using a commercial ELISA kit. Median irisin concentrations were 9.03 (5.81–12.22) μg/mL and 4.2 (3.39–7.62) μg/mL, respectively, in each group. There was no correlation between irisin and disease severity. Any correlations between irisin, and lactate dehydrogenase (LDH), international normalization ratio (INR), Alanine aminotransferase (ALT), aspartate aminotransferase (AST), platelets, activated partial thromboplastin time (aPTT), D-dimer and hemoglobin, were also investigated. There were statistically significant positive correlations between the values of irisin, and platelet (p = 0.005, r: 0.369), ALT (p = 0.049, r: 0.261), INR (p = 0.006, r: 0.359) and aPTT values (p = 0.002, r: 0.405). A negative correlation was also found between the values of irisin and LDH (p = 0.008, r: -0.348). No correlations were determined between the values of irisin, and AST, hemoglobin and D-dimer. These results suggest that irisin may have a role in CCHF.</p>
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 70 (5), 475-478, 2017
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001206242163840
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- NII論文ID
- 130006096753
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 028534759
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- PubMed
- 28250262
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可